INHIBITORS OF ENZYME O6-ALKYLGUANINE-DNA-METHYLTRANSFERASE FOR CANCER TREATMENT

摘要

The invention relates to the use of compounds derived from piperadinyl-methyl-tetrazole-quinolinone and derived from diphenyl-triazolo- pyrimidine as inhibitors of the reparative action of the DNA produced by enzyme O6-alkylguanine-DNA-methyltransferase, and to pharmaceutical compositions containing same, for the preparation of coadjuvant drugs for use in antitumour therapy using alkylating agents.