Chemical entity derived from pirazolopirimidina, inhibiting the ubiquitin Activating Enzyme 1 Crystalline anhydrous form; Form; 2 Crystalline Monohydrate; Pharmaceutical Composition and Method for treating cancer; and use for the treatment of Lung Cancer, ovarian cancer, colon cancer Breast Cancer, or Lymphoma.

摘要

Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formulaor a pharmaceutically acceptable salt thereof, wherein Y isand W, Z, X, R, Rand Rare defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.