A Chemical entity comprising the sulphamate Compound {(1S, 2S, 4R) - 4 - (3 - (1R, 2S) - 5 - Chloro - 2 - methoxy - 2,3 Dihydro 1h inden - triazin-1-yl amino} pyrimidin-4-yl) oxy - 2 - hidroxiciclopentil} Methyl; inhibitor of the Activation of the Enzyme SDDS - 8; Crystalline form of the compound I; prodrug; dosage composition Utica; a method for treating cancer.

摘要

Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1 S ,2 S ,4 R )-4-[(6-{[(1 R ,2 S )-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.