Crystalline form of sulphamate {(1S, 2S, 4R) - 4 - (3 - (1R, 2S) - 5 - Chloro - 2 - methoxy - 2,3 Dihydro 1h inden - triazin-1-yl amino} pyrimidin-4-yl) oxy methyl - 2 - hidroxiciclopentil, Pharmaceutical compositions containing the same and use for treating cancer

摘要

1. Property 1: a chemical entity composed of [1s, 2S, 4R) - 4 - [(6 - [1R, 2S) - 5-chloro-2-thyroid-2, 3-dihydro-1h-inden-1-il] amine} pirimidin-4-il] - 2-hydrocyclopentil} methyl compounds. 115. Claim 2: the chemical entity of claim 1, the chemical entity of which is a hydrochloride or a solution acceptable on a drug. 13. Claim 3: the chemical entity of claim 2, the chemical entity of which is form I, essentially crystalline. 1. Claim 13: any claimed chemical entity 3-7,1. Form I is characterized by X-ray powder diffraction (XRPD) mode with a reference peak of 4.5 ± 0.3 ° 2q,It has a 3-degree 2q peak4.4.5.3.8.8 degrees9.9,Ten point one10.7 degrees11.4%12.7 degrees15,15.5,16.8 degrees17.3.17.9,18.2%19.5,20.3.21.2. And 21.9. On benchmarks.