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Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

机译：发现TAK-981，是治疗癌症的SUMO-活化酶的一流抑制剂

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Steven P. Langston; Stephen Grossman; Dylan England; Roushan Afroze; Neil Bence; Douglas Bowman; Nancy Bump; Ryan Chau; Bei-Ching Chuang; Christopher Claiborne; Larry Cohen; Kelly Connolly; Matthew Duffey; Nitya Durvasula; Scott Freeze; Melissa Gallery; Katherine Galvin; Jeffrey Gaulin; Rachel Gershman; Paul Greenspan; Jessica Grieves; Jianping Guo; Nanda Gulavita; Shumet Hailu; Xingyue He; Kara Hoar; Yongbo Hu; Zhigen Hu; Mitsuhiro Ito; Mi-Sook Kim; Scott Weston Lane; David Lok; Anya Lublinsky; William Mallender; Charles McIntyre; James Minissale; Hirotake Mizutani; Miho Mizutani; Nina Molchinova; Koji Ono; Ashok Patil; Mark Qian; Jessica Riceberg; Vaishali Shindi; Michael D. Sintchak; Keli Song; Teresa Soucy; Yana Wang; He Xu; Xiaofeng Yang; Agatha Zawadzka; Ji Zhang; Sai M. Pulukuri;
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1. Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer [J] . Langston Steven P., Grossman Stephen, England Dylan, Journal of Medicinal Chemistry . 2021,第5期

机译：发现TAK-981，是癌症癌症的一流抑制剂，用于治疗癌症
2. Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers [J] . Popovici-Muller Janeta, Lemieux Rene M., Artin Erin, ACS medicinal chemistry letters . 2018,第4期

机译：发现AG-120（Ivosidenib）：用于治疗IDH1突变癌的一类突变体IDH1抑制剂
3. Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme [J] . Robert S. Magin, Laura M. Doherty, Sara J. Buhrlage Cell chemical biology . 2019,第2期

机译：发现SUMO E1活化酶的一流共价抑制剂
4. Nonclinical Discovery and Development of Bortezomib (PS-341, VELCADE~(R)) a Proteasome Inhibitor for the Treatment of Cancer [C] . Bouchard PR, Juedes M, Nix D, Annual Meeting of the American Society for Veterinary Clinical Pathology . 2004

机译：Bortezomib（PS-341，Velcade〜（R）的非临床发现和发展）一种治疗癌症的蛋白酶体抑制剂
5. Multi-Target Pharmacology of Small Molecule Drugs and First-In-Class Inhibitors Discovery [D] . Shi, Da. 2020

机译：小分子药物的多目标药理学和一流的抑制剂发现
6. AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924 a first-in-class NEDD8-activating enzyme (NAE) inhibitor [O] . Xiaoyu Chen, Danrui Cui, Yanli Bi, 2018

机译：AKT抑制剂MK-2206使乳腺癌细胞对MLN4924敏感MLN4924是一流的NEDD8激活酶（NAE）抑制剂
7. Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer [O] . -1

机译：发现TAK-981，是治疗癌症的SUMO-活化酶的一流抑制剂

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

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