POTENTIALS OF GLUTAMATE RECEPTORS.

摘要

A compound of formula I ** (See formula) ** in which R1 is selected from the group consisting of C1-C5 alkyl, C3-C7 cycloalkyl, C4-C8 cycloalkylalkyl, phenyl and substituted phenyl; R2 is selected from the group consisting of hydrogen, C1-C5 alkyl, substituted C1-C5 alkyl, halo, phenyl, substituted phenyl, C1-C3 fluoroalkyl, CN, CO2R3, thiophenyl, substituted thiophenyl, thiazolyl, substituted thiazoyl, furanyl, substituted furanyl, pyridinyl, substituted pyridinyl, oxazolyl, substituted oxazolyl, isothiazolyl, substituted isothiazoyl, isoxazolyl, substituted isoxazolyl, 1,2,4-oxadiazolyl, substituted 1,2,4-oxadiazolyl, pyrimidinyl, substituted pyrimidinyl, pyridazinyl and substituted; X is selected from the group consisting of O, S (O) m and NR3; Y is selected from the group consisting of C1-C3 alkanediyl and substituted C1-C3 alkanediyl; Ar1 and Ar2 are independently selected from the group consisting of phenylene, substituted phenylene, thiophenediyl, I thiophenediyl, substituted thiazolediyl, I substituted thiazolediyl, furanediyl, I furanediyl substituted pyridinediyl I pyridinediyl, substituted oxazolediyl, I oxazolediyl substituted isothiazolediyl, I isothiazolediyl, substituted isoxazolediyl, I isoxazolediyl substituted, pyrimidinediyl, substituted pyrimidinediyl, pyridazinediyl, substituted pyridazinediyl and 1,2,4-oxadiazol-3,5-diyl; L is selected from the group consisting of -G-SO2N (R3) -J-, -G- (R3) NSO2-J-, -GC (= O) N (R3) -J-, -G- (R3 ) NC (= O) -J- and -GN (R3) C (= O) N (R3) -J-; G and J are independently selected from the group consisting of a bond and C1-C3 alkanediyl; R3 is independently hydrogen or C1-C5 alkyl; Z is selected from the group consisting of (CH2) nCOOH, and ** (See formula) ** m is 0, 1 or 2; n and q are 0; as long as Z is attached to the 1-3 (meta) or 1-4 (para) position when R1 is methyl, R2 is propyl, R3 is hydrogen, X is O, Y is -CH2-, L is -G- ( R3) NC (= O) -J-, G is a bond, J is a bond or -CH2-, Ar1 and Ar2 are phenylene, Z is (CH2) nCOOH and n is 0; and pharmaceutically acceptable salts thereof.