MEDICINAL ADMINISTRATION SYSTEM UNDERSTANDING A TETRAHYDROXYLED STROGEN FOR USE IN HORMONAL ANTI-CONCEPTION.

摘要

Use of an estrogenic component selected from the group consisting of: substances represented by the following formula ** (See formula) ** in which formula R1, R2, R3, R4 are independently a hydrogen atom, a hydroxyl group or a alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; and no more than 3 of R1, R2, R3, R4 are hydrogen atoms; the precursors capable of releasing a substance according to the aforementioned formula when used in the present method, whose precursors are derived from the substances represented by the formula, where the hydrogen atom of at least one of the hydroxyl groups in said formula has been been substituted by an acyl radical of a hydrocarbon, sulfonic acid or sulfamic carboxylic acid having 1-25 carbon atoms; tetrahydrofuranyl; tetrahydropyranal; or a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue; and mixtures of one or more of the aforementioned substances and / or precursors; in the production of a pharmaceutical composition for use in a contraceptive method in female mammals, the method comprising parenteral or rectal administration of said estrogenic component and a progestogenic component to a female with reproductive capacity in an amount effective to inhibit ovulation and where The method does not employ co-administration of a luteinizing hormone releasing hormonal composition (LHRH) or a gonadotropin releasing hormonal composition (gnRH).