AMIDINE DERIVATIVES OF 2-HETEROARIL-QUINAZOLINAS AND QUINOLINAS; POWERFUL ANALGESIC AND ANTI-INFLAMMATORY AGENTS.

摘要

Compounds of formula (I): ** (See formula) ** in which: - X is independently selected from a carbon atom or a nitrogen atom; - Z and Y are independently selected from an oxygen atom (-O-), a sulfur atom (-S-) or the groups: -CH2-, -CHR2-, -CH =, -CR2 =; - Q is independently selected from the groups: -CH2-, -CHR2-, -CH =, -CR2 =, -CH2-CH2- or -CHR2-CH2-; with the proviso that the combination of the groups Y, Z and Q results in a hexa-atomic or penta-atomic benzo-condensed heterocycle, preferably selected from 1,3-benzodioxol, 1,3-benzodithiol, benzofuran, 2,3- dihydrobenzofuran, benzothiophene, 2,3-dihydrobenzothiophene, 2H-3,4-dihydrobenzopyran, 2H-3,4-dihydrobenzothiopyran, [1,4] -benzodioxine and 2,3-dihydro- [1,4] benzodioxine- (1, 4-benzodioxane); R1 is independently selected from C1-C4 alkyl or C3-C4 cycloalkyl; the C1-C4 alkyl group being a linear or branched, saturated or unsaturated hydrocarbon chain; R2 is independently selected from C1-C4 alkyl and alkoxy (-OR1); the compounds of formula (I) being in the form of a free base or as their pharmaceutically acceptable salt, hydrate or solvate.