COMPOSITE OF HYDROPHYLIC POLYMERIC OLIGOPEPTIDE HYDROPHYLIC AND MEDICINES, MEDICAL COMPOSITION THAT INCLUDES THE MENTIONED COMPOUND AND THE USE OF THE COMPOSITE MENTIONED IN MEDICINES.

摘要

A conjugate of hydrophilic polymeric polycarboxylic oligopeptide and drug molecule of the following formula: ** (See formula) ** where: P is a water-soluble polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, polyvinyl alcohol, polyacrylmorpholine and copolymers thereof; m is an integer from 2-12; j is an integer from 1-6; Ri is a group selected from the group consisting of H, C1-12 alkyl, substituted aryl, aralkyl, heteroalkylene and substituted alkyl; X is a connection group selected from (CH2) i, (CH2) and OCO, (CH2) i NHCO and (CH2) iCO, where i is an integer from 0-10; Z is a connection group selected from O and NH; and TA is any one selected from the group consisting of cinobufagina, glycyrrhizinic acid, paclitaxel, camptothecin, hydroxycamptothecin and etoposide.