COMPOUND OF HYDROPHILIC POLYMER-POLYCARBOXYL OLIGOPEPTIDE AND MEDICINES, MEDICAL COMPOSITE COMPRISING ABOVE COMPOUND AND USE OF ABOVE COMPOUND IN MEDICINES

摘要

The present invention relates to a conjugate of hydrophilic polymer-multicarboxyl oligopeptide and drug molecule of the following formula: CHEM wherein: P is a water soluble polymer; m is an integer of 2 SIMILAR 12; j is an integer of 1 SIMILAR 6; Ri is a group selected from H, C1-12 alkyl, substituted aryl, aralkyl, heteroalkyl and substituted alkyl; X and Z are linking groups; and TA is drug molecule. The conjugate has low toxicity and an ability to carry more than one drug molecule to improve solubility, sustain and control drug release, and has a remarkably enhancing effect especially to antitumor drug such as paclitaxel and camptothecin etc.