Method to explore the presence of a genetic defect associated with deep venous thrombosis.

摘要

A method of screening an individual to determine an increase of venous thrombosis, in particular deep venous thrombosis, comprising detecting the presence in the individual's genome of a target genetic marker of an increased risk of venous thrombosis, in particular thrombosis risk deep vein, wherein the genetic marker is haplotype 2 of the fibrinogen gene & gamma; (FGG-H2) as indicated in Figure 5A (SEQ ID NO: 21) and wherein the presence of FGG-H2 is associated with the presence of a set of one, two, three or four mutations in the nucleic acid material encoding the fibrinogen gamma ;, & mutations from the group consisting of 129A / T (rs2066854), 7874G / a (rs2066861), 9615C / T (rs2066864) and 10034C / T (rs2066865) being selected.