METHOD OF SCREENING FOR THE PRESENCE OF A GENETIC DEFECT ASSOCIATED WITH DEEP VENOUS THROMBOSIS

摘要

The present invention relates to a method for screening an individual for the presence in his/her genome of a genetic marker that is indicative of an increased risk of deep venous thrombosis, wherein the genetic marker is haplotype 2 of the fibrinogen Ϝ gene (FGG-H2) as given in Figure 5A. The genetic marker comprises a set of one, two, three or four mutations in the nucleic acid material encoding fibrinogen Ϝ, the mutations being selected from the group consisting of 129A/T (rs2066854) , 7874G/A (rs20668βl) , 9615'C/T (rs2066864) and 10034C/T (rs2066865) .