peptidic compounds and their derivatives for the treatment of human disease by inhibiting the signaling pathway by growth factors.

摘要

A peptide compound selected from the group consisting of (a) peptides consisting of the amino acid sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2 (b) peptides consisting of any of following amino acid sequences: amino acids 2-14 of SEQ ID NO: 1 or 2; amino acids 2-13 of SEQ ID NO: 1 or 2; amino acids 2-12 of SEQ ID NO: 1 or 2; amino acids 2-11 of SEQ ID NO: 1 or 2; amino acids 3-14 of SEQ ID NO: 1 or 2; amino acids 3-13 of SEQ ID NO: 1 or 2; amino acids 3-12 of SEQ ID NO: 1 or 2; amino acids 3-11 of SEQ ID NO: 1 or 2; amino acids 4-14 of SEQ ID NO: 1; amino acids 4-13 of SEQ ID NO: 1 or 2; amino acids 4-12 of SEQ ID NO: 1 or 2; amino acids 4-11 of SEQ ID NO: 1 or 2; amino acids 5-14 of SEQ ID NO: 1 or 2; amino acids 5-13 of SEQ ID NO: 1 or 2; amino acids 5-12 of SEQ ID NO: 1 or 2; amino acids 5-11 of SEQ ID NO: 1 or 2; amino acids 6-14 of SEQ ID NO: 1 or 2; amino acids 6-13 of SEQ ID NO: 1 or 2; amino acids 6-12 of SEQ ID NO: 1 or 2; amino acids 6-11 of SEQ ID NO: 1 or 2; amino acids 7-14 of SEQ ID NO: 1 or 2; amino acids 7-13 of SEQ ID NO: 1 or 2; amino acids 7-12 of SEQ ID NO: 1 or 2; amino acids 7-11 of SEQ ID NO: 1 or 2; and (c) heterologous fusion peptides consisting of (a) or (b) fused with a heterologous amino acid sequence.