ZOLEDRONIC ACID OR SALTS THEREOF FOR USE IN THE TREATMENT OF CONDITIONS OF ABNORMALLY INCREASED BONE TURNOVER

摘要

Bisphosphonates, in particular more potent N-bisphosphonates such aszoledronic acid and derivatives, can be used with satisfactory results forprolonged inhibition of bone resorption in conditions of abnormally increasedbone turnover, e.g. osteoporosis, by intermittent administration, wherein theperiods between bisphosphonate administrations are longer than was previouslyconsidered appropriate, e.g. a dosing interval of at least about 6 months orless frequently.