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MODIFIED CIPA GENE FROM CLOSTRIDIUM THERMOCELLUM FOR ENHANCED GENETIC STABILITY

机译：球孢梭菌修饰的CIPA基因增强了遗传稳定性

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摘要

Bacteria consume a variety of biomass-derived substrates and produce ethanol.The scaffoldin gene cipA fromClostridium thermocellum is modified to generate a mutated gene with enhancedgenetic stability. This mutated cipA gene can beintroduced into a heterologous host, such as Thermoanaerobacteriumsaccharolyticum. Other cellulosome components may beintroduced into the host to build a full-sized cellulosome in T.saccharolyticum. Manipulation of the scaffoldin genes provides anew approach for enhancing ethanol production by biomass-fermentingmicroorganisms.

机译：细菌消耗各种生物质衍生的底物并产生乙醇。来自的scaffoldin基因cipA修饰了热梭菌产生了一个增强的突变基因。遗传稳定性。这个突变的cipA基因可以是引入异源宿主，如嗜热厌氧杆菌解糖。其他纤维素成分可能是被引入宿主体内以在T细胞中构建完整的纤维素体解糖。操纵脚手架基因提供了一个生物质发酵提高乙醇产量的新方法微生物。

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公开/公告号CA2759245A1

专利类型
公开/公告日2010-10-28

原文格式PDF
申请/专利权人 THE TRUSTEES OF DARTMOUTH COLLEGE;
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申请/专利号CA20102759245
发明设计人 CURRIE DEVIN HEDLEY;MCBRIDE JOHN;GUSS ADAM;
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申请日2010-04-21
分类号C12N15/31;C12N1/21;C12N15;C12N15/74;C12P7/10;
国家 CA
入库时间 2022-08-21 18:42:01

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