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MODIFIED CIPA GENE FROM CLOSTRIDIUM THERMOCELLUM FOR ENHANCED GENETIC STABILITY

机译：嗜热梭状芽孢杆菌的修饰的 CIPA 基因用于增强遗传稳定性

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Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic stability. This mutated cipA gene can be introduced into a heterologous host, such as Thermoanaerobacterium saccharolyticum. Other cellulosome components may be introduced into the host to build a full-sized cellulosome in T. saccharolyticum. Manipulation of the scaffoldin genes provides a new approach for enhancing ethanol production by biomass-fermenting microorganisms. 展开▼

机译：细菌消耗各种生物质衍生的底物并产生乙醇。修饰 Clostridium thermocellum 的scaffoldin基因 cipA 以产生具有增强的遗传稳定性的突变基因。可以将这种突变的 cipA 基因引入异源宿主，例如 Thermoanaerobacterium saccharolyticum 。可以将其他纤维质成分引入宿主，以在溶糖衣原体中构建全尺寸的纤维质粒。脚手架基因的操纵提供了一种新的方法来提高生物质发酵微生物的乙醇生产。 展开▼

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公开/公告号WO2010124000A3

专利类型

公开/公告日2011-03-24

原文格式PDF

申请/专利权人 THE TRUSTEES OF DARTMOUTH COLLEGE;CURRIE DEVIN HEDLEY;MCBRIDE JOHN;GUSS ADAM;
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申请/专利号WO2010US31907

发明设计人 CURRIE DEVIN HEDLEY;MCBRIDE JOHN;GUSS ADAM;
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申请日2010-04-21

分类号C12N15/31;C12N15/74;C12R1/145;

国家 WO

入库时间 2022-08-21 18:00:41

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