NETRIN-1 OVEREXPRESSION AS A BIOLOGICAL MARKER AND A SURVIVAL FACTOR FOR AGGRESSIVE NEUROBLASTOMA

摘要

The present invention comprises an in vitro method for predicting whether neuroblastoma (NB) identified in a patient is a metastatic and/or an aggressive NB, and/or a NB having a poor prognosis, or for predicting a NB having a good prognosis. The present invention further comprises a method for preventing and/or treating such NB cancer and a method for selecting a therapeutic compound for the prevention or the treatment of such metastatic and/or aggressive NB. Finally, the present invention is directed to a method for determining in vitro the efficiency of an anti-NB cancer treatment or for in vitro selecting patients who respond to a specific anti-NB treatment and wherein said NB cancer is a metastatic and/or aggressive NB related to the presence of an overexpression of netrin-1 in the tumoral tissue.