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ENHANCEMENT OF TRANSGENE EXPRESSION FROM VIRUS-BASED VACCINE VECTORS USING SUPPRESSORS OF THE TYPE 1 INTERFERON RESPONSE
ENHANCEMENT OF TRANSGENE EXPRESSION FROM VIRUS-BASED VACCINE VECTORS USING SUPPRESSORS OF THE TYPE 1 INTERFERON RESPONSE
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机译:使用1型干扰素反应的抑制子增强基于病毒的疫苗载体的转基因表达
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摘要
Baculovirus vectors with improved ability to express transgenes are provided. The baculovirus vectors are genetically engineered to contain and express nucleic acid sequences that encode one or more proteins that interfere with mammalian host cell type I interferon (IFN) responses. Thus, the expression of transgenes encoded by the baculovirus vector is not inhibited by a type I DFN response, and the transgenes are freely expressed in mammalian host cells. Alternatively, baculovirus vectors with nucleotide sequences encoding one or more genes of interest (e.g. tuberculosis or malarial antigens) are co-administered with one or more proteins that interfere with mammalian host cell type I IFN responses; or with viral vectors (e.g. adenovectors) that express one or more proteins that interfere with mammalian host cell type I IFN responses.
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