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ADHESIN-ENTEROTOXIN CHIMERA BASED IMMUNOGENIC COMPOSITION AGAINST ENTERTOXIGENIC ESCHERICHIA COLI
ADHESIN-ENTEROTOXIN CHIMERA BASED IMMUNOGENIC COMPOSITION AGAINST ENTERTOXIGENIC ESCHERICHIA COLI
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机译:基于钙粘蛋白-肠毒素的抗肠毒素的免疫原性组合物
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摘要
The subject matter relates to an immunogenic composition composed of a chimetric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.
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