A METHOD FOR THE SYSTEMATIC EVALUATION OF THE PROGNOSTIC PROPERTIES OF GENE PAIRS FOR MEDICAL CONDITIONS, AND CERTAIN GENE PAIRS IDENTIFIED

摘要

A method is proposed identification of pairs of genes for which the respective gene expression values in a subject are statistically significant in relation to a medical condition, for example cancer, or more particularly breast cancer. Many pairs of genes are generated, and for each pair of genes clinical data is used to fit a statistical model to obtain the statistical significance of the ratio of the corresponding expression values. The clinical data characterizes for each of the patients the level of expressions of the genes and times until a clinical endpoint of interest.