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Anti-tumor activity of small double-stranded oligodeoxynucleotides targeting telomerase RNA
Anti-tumor activity of small double-stranded oligodeoxynucleotides targeting telomerase RNA
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机译:靶向端粒酶RNA的小双链寡聚脱氧核苷酸的抗肿瘤活性
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摘要
The invention refers to an antitumor and/or anti-metastatic therapeutic, comprising siDNA oligonucleotides that bind to one or more RNA target regions of the RNA component of telomerase. The siDNA oligonucleotides comprise of one strand which is fully complementary to the template region of the RNA component of Telomerase and a second strand partially complementary to the antisense strand. The siDNA oligos bind the Telomerase RNA and lead to its inactivation.
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