2-(2-OXO-2-PHENYLETHYLSULFANYL)-BENZIMIDAZZOLE-4-CARBOXIMIDE DERIVATIVE HAVING EFFECT OF PREVENTING OR TREATING DISEASES CAUSED BY OVER-ACTIVATION OF PARP-1

摘要

PURPOSE: A 2-(2-oxo-2-phenylethylsulfanyl)-benzimidazole-4-carboximide derivative is provided to prevent or treat diseases caused by over-activation of poly(ADP-ribose)polymerase-1(PARP-1) and protect heart during surgery or drug therapy.;CONSTITUTION: A 2-(2-oxo-2-phenylethylsulfanyl)-benzimidazole-4-carboximide derivative is denoted by chemical formula 1. The 2-(2-oxo-2-phenylethylsulfanyl)-benzimidazole-4-carboximide derivative is prepared by performing alkylation of a compound of chemical formula 2 with a compound of chemical formula 3 under the presence of basic catalyst or without the catalyst. A pharmaceutical composition for preventing or treating diseases caused by over-activation of poly(ADP-ribose)polymerase-1(PARP-1) contains the 2-(2-oxo-2-phenylethylsulfanyl)-benzimidazole-4-carboximide derivative or its pharmaceutically acceptable salt as an active ingredient. The disease is ischemic disease or neurodegenerative disease.;COPYRIGHT KIPO 2010