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NOVEL PYROLLOamp;lsqb;3,2-Bamp;rsqb;PYRIDINE DERIVATIVE HAVING MELANOMA ANTI-PROLIFERATIVE ACTIVITY AND A PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MELANOMA CONTAINING THE SMAE
NOVEL PYROLLOamp;lsqb;3,2-Bamp;rsqb;PYRIDINE DERIVATIVE HAVING MELANOMA ANTI-PROLIFERATIVE ACTIVITY AND A PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MELANOMA CONTAINING THE SMAE
PURPOSE: A novel pyrollo[3,2-b]pyridine derivative and a pharmaceutical composition for preventing or treating melanoma containing the same are provided to ensure high anti-proliferative activity to melanoma cells.;CONSTITUTION: A pyrollo(3,2-b)pyridine derivative is denoted by chemical formula 1. A method for preparing the pirrolo(3,2,-b)pyridine derivative comprises: a step of coupling 1-iodine-4-nitrobenze to a compound of chemical formula 2 to obtain a compound of chemical formula 3; a step of reducing the compound of chemical formula 3 to obtain a compound of chemical formula 4; and a step of coupling the compound of chemical formula 4 with a phenylcarboxylic acid or amine derivative which trifluoromethyl, halogen, morpholine, piperazine. A pharmaceutical composition for preventing or treating melanoma contains the pyrollo(3,2-b)pyridine derivative or pharmaceutically acceptable salt as an active ingredient.;COPYRIGHT KIPO 2010
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