PHARMACEUTICAL FORMULATION HAVING IMPROVED DISSOLUTION RATE AND STABILITY FOR ORAL ADMINISTRATION CONTAINING PELUBIPROFEN

摘要

PURPOSE: one kind pelubiprofen containing oral formulation is provided to improve release rate and stability, by reducing impurity and to ensure snap action and bioavilability. ;CONSTITUTION: medicinal preparation for oral administration with improved release rate and stability pelubiprofen include chemical formula 1 have average particle size be 1-30 uh be used as active constituent. The pharmaceutical preparation also contains excipient, lactose, calcium monohydrogen phosphate, starch or polyalcohol, the hydroxy propyl cellulose or polysaccharide of binder, the magnesium stearate or talcum of disintegrating agent carboxymethyl base cellulose calcium, low substituted hydroxypropyl cellulose or starch or lubricant. The polyalcohol is mannitol, isomalt or xylitol. Polysaccharide xanthan gum or carragheen. The form of the pharmaceutical preparation to use tablet, granule, capsule or dry syrup. ;The 2010 of copyright KIPO submissions