Amino derivatives of adamantane have antiviral activity against influenza viruses

摘要

Amino derivatives of general formula adamantane series !! where R = OH, R1 = R2 = R3 = H, R4 = C2H5, X = Cl, n = 1 (I); ! R = Br, R1 = R2 = R3 = H, R4 = C2H5, X = Br, n = 1 (II); ! R = OH, R1 = R2 = H, R3 + R4 = -CH2CH2CH2CH2-, X = Cl, n = 1 (III); ! R = Br, R1 = R2 = H, R3 + R4 = -CH2CH2CH2CH2-, X = Br, n = 1 (IV); ! R = OH, R1 = R2 = CH3, R3 = R4 = H, X = Cl, n = 1 (V); ! R = CH3, R1 = -CH2OH, R2 = R3 = R4 = H, X = Cl, n = 1 (VI); ! R = R1 = R2 = R3 = H, R4 = -CH2CH2NH2, X = Cl, n = 2 (VII),! possess antiviral activity against influenza virus.