METHOD OF DETERMINING DEGREE OF PATHOGENICITY OF B COXSACKIE VIRUS STRAIN

摘要

A method for determining the degree of pathogenicity Coxsackie strain of the virus, including the study of strain Coxsackie B virus, obtained directly from the patient - a field strain and determination of the degree of pathogenicity field strain of the study, characterized in that the exploring neyropatogennost field strain Coxsackie B virus, the studies carried out in a single slot of linear one litter mice aged 2 to 4 days from the uterus, which mice were divided into two groups, one of which is artificially infect vaniyu field strain Coxsackie B virus, and then perform research neyropatogennosti field strain mice infected naturally, which is fixed pronounced signs of lesions of the central nervous system and comparing their character with severe signs of lesions of the central nervous system, characteristic taken as reference strains Coxsackie B, while taking as reference the known strains of the prototype and the epidemic Coxsackie B viruses, and then, based on the comparison made vyvo of the degree of pathogenicity field strain Coxsackie B virus, namely the coincidence character pronounced signs of lesions of the central nervous system with symptoms characteristic of the prototype and epidemic Coxsackie strains B ascertain that the degree of pathogenicity field strain of coxsackie B corresponds epidemic, otherwise ascertain, that the degree of pathogenicity of the strain field Coxsackie B corresponds interepidemic.