DIALKYLPHENYLIC DERIVATIVES HAVING AGONISTIC ACTIVITY AGAINST β2-ADRENERGIC RECEPTORS AND ANTAGONISTIC ACTIVITY AGAINST MUSCARINE RECEPTORS

摘要

1. The compound of formula I:! ! in which R1 represents methyl or ethyl; ! R2 is methyl or ethyl; ! or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. ! 2. The compound according to claim 1 of formula II:! ! in which R1 represents methyl or ethyl; ! R2 is methyl or ethyl; ! or a pharmaceutically acceptable salt thereof. ! 3. The compound according to claim 1 of formula IIa:! ! 4. The compound according to claim 1, where the compound is a pharmaceutically acceptable salt of the compounds of formula IIa:! ! 5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to any one of claims 1 to 4. ! 6. A pharmaceutical composition comprising:! (a) a compound according to any one of claims 1 to 4; ! (b) a steroidal anti-inflammatory agent; and! (c) a pharmaceutically acceptable carrier. ! 7. The combination of therapeutic agents, including:! (a) a compound according to any one of claims 1 to 4; and! (b) a steroidal anti-inflammatory agent. ! 8. A set including:! (a) a first pharmaceutical composition comprising a compound according to any one of claims 1 to 4 and a first pharmaceutically acceptable carrier; and! (b) a second pharmaceutical composition comprising a steroidal anti-inflammatory agent and a second pharmaceutically acceptable carrier; where the first and second pharmaceutical compositions are separate pharmaceutical compositions. ! 9. A method of treating a lung disease, the method comprising administering to a patient in need of treatment a therapeutically effective amount of a compound according to any one of claims 1 to 4. ! 10. A method of treating chronic obstructive pulmonary disease or asthma, the method comprising administering to a patient therapeutically effective