A NEW APPROACH TO TREATMENT OF INCREASED IN-ORGAL PRESSURE

摘要

1. The use of an antisecretory protein, its homologue, derivative and / or fragment having antisecretory activity, and / or its pharmaceutically acceptable salt for the preparation of a pharmaceutical composition for the prevention and / or treatment of increased intraocular pressure. ! 2. The use according to claim 1, where the specified antisecretory protein consists of a sequence corresponding to the following formulas:! X1-V-C-X2-X3-K-X4-R-X5,! where X1 is I, amino acids 1-35 SEQ ID NO: 6 or absent, X2 is H, R or K, X3 is S or L, X4 is T or A, X5 is amino acids 43-46, 43-51, 43- 80 or 43-163 SEQ ID NO: 6 or absent. ! 3. The use according to claim 1, where this antisecretory protein is a protein with the amino acid sequence shown in SEQ ID NO: 6, its homologue, derivative and / or fragment containing amino acids 38-42 of SEQ ID NO: 6. ! 4. The use according to claim 1, where the specified fragment contains the amino acid sequence shown in SEQ ID NO: 1. ! 5. The use according to claim 1, where the specified fragment contains the amino acid sequence shown in SEQ ID NO: 2. ! 6. The use according to claim 1, where the specified fragment contains the amino acid sequence shown in SEQ ID NO: 3! 7. The use according to claim 1, where the specified fragment contains the amino acid sequence shown in SEQ ID NO: 4. ! 8. The use according to claim 1, where the specified fragment contains the amino acid sequence shown in SEQ ID NO: 5. ! 9. The use according to any one of the preceding paragraphs, where the specified pharmaceutical composition contains one or more of the fragments according to claims 1 to 8. ! 10. The use according to any one of claims 1 to 8, where the intraocular pressure is 22 or more mm Hg. ! 11. The use according to any one of claims 1 to 8, where