DERIVATIVES OF XANTHINE WITH ANTI-PROLIFERATING ACTIVITY, MODULATORS OF CELLULAR DIFFERENTIATION

摘要

1. xanthine derivatives or pharmaceutically acceptable derivatives of formula 1! ! where! R1 is CH3, R2 - CH3; R3 - halogens F, Cl, Br, I; R4 - hydrogen; ! R1 is CH3, R2 - CH3; R3 - hydrogen, halogens F, Cl, Br, I; R4-CH2COOH; ! R1 is hydrogen, R2 - CH3; R3 - halogens F, Cl, Br, I; R4 - CH3. ! 2. A compound according to claim 1, wherein R1, R2 and R4 each independently is CH3, a R3 - hydrogen: 1,3,7, -trimetilksantin (caffeine). ! 3. A compound according to claim 1, wherein R1 and R3 each is independently hydrogen, a R2 and R4 each independently of the other is CH3: 3.7, -dimetilksantin (theobromine). ! 4. A compound according to claim 1, wherein R1 and R2 represent each independently CH3, a R3 and R4 each independently represents H: 1.3, -dimetilksantin (theophylline). ! 5. A compound according to claim 1, wherein R1 and R2 represent each independently CH3, a R3 is Cl and R4 is H: 8-chloro-1,3, -dimetilksantin (8-hlorteofillin). ! 6. A compound according to claim 1, wherein R1 and R2 represent each independently CH3, a R3 is Br and R4 is H: 8-bromo-1,3, -dimetilksantin (8-bromo-theophylline). ! 7. A compound according to claim 1, wherein R1 and R2 represent each independently CH3, a R3 is H and R4 is CH2COOH: 1.3 -dimetilksantin-7-acetate (theophylline-7-acetate). ! 8. A method of slowing the rate of proliferation of tumor cells, comprising administering to the environment an acceptable amount of an active compound, characterized in that as active compound a compound administered according to any of claims 1-7. ! 9. A method according to claim 8, characterized in that said compound is administered in an amount of 1 mM. ! 10. The process of differentiation induction in cells of mouse melanoma B16-F10, comprising administering to the environment an acceptable amount of active