FLUORENE DERIVATIVES WITH ANTI-PROLIFERATING ACTIVITY, MODULATORS OF CELLULAR DIFFERENTIATION, METHOD OF RETARDING THE SPEED OF TUMOR CELL PROLIFERATION, METHOD OF INDUCTING THE DIFFERENTIATION IN MELANOMA CELLS OF MICE

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to substituted fluorene compounds and specifically to a compound of formula where R₁ denotes a NH₂-group or a Br atom; R₂ denotes hydrogen or halogen; R3 is selected from the following group: oxygen, aminoalkyl group =N-alkyl, where alkyl C₁-C₁₂ (having normal or branched structure), aminoaryl group=N-aryl, where aryl: phenyl, naphthyl, aminoheteroaryl group=N-heteroaryl, where heteroaryl: pyridine, quinoline, phenylamine. The invention also relates to a method of slowing down proliferation of tumour cells, involving addition of an acceptable amount of an active compound of formula (1) into the medium, and to a method of inducing differentiation in mouse melanoma cells B16-F10.;EFFECT: novel compounds which can be active agents which inhibit tumour proliferation and activate differentiation in mouse melanoma cells B16-F10 are obtained and described.;11 cl, 8 tbl, 11 dwg