METHOD FOR DETERMINING severity of the disease and treatment efficacy in patients with bronchopulmonary diseases

摘要

A method of diagnosing a disease severity and treatment efficacy in patients with bronchopulmonary diseases, comprising the selection of the material, separation therefrom cellular substances, preparing it to the study, determination of the alteration of cells by measuring their apoptosis, characterized in that as the test material is induced sputum of patients and a healthy person, in cellular substance further determine the amount of alteration of cells by necrosis, the apoptosis and necrosis objectified indicators elyayut with two or more surveys at intervals of 1-3 days, the figures obtained are expressed as the apoptotic index (AI) and necrotic index (MI) was calculated index of alteration of cells (IAC) by the formula: IAK = IN / AI! where IN - necrosis index; ! AI - apoptotic index! wherein the severity of the disease is determined by comparing the alterations in the index patient indicator cells with the index index alteration healthy individual cells and for diagnosing lung bronchopulmonary diseases IAK at rates greater than 1.5, average 1.0 to 1.0 and less heavy, and efficacy of treatment determined by comparing the initial indicators of alteration patient cells index index index of alteration after the treatment, and the treatment of diagnosed positive trend with an increase in the IAK to the values ​​for healthy individuals 2,0.