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PLANNING BIOLOGICALLY GUIDED ADAPTIVE THERAPY

机译:规划生物学指导的适应性治疗

摘要

1. A therapy destination device (118) that uses a pathology model (122) and an archive of data (124) of object-specific biological parameters to establish the desired therapy (D) for application to an object (101), while the pathology model simulates the pathology response to therapy, and the archive of biological parameter data includes the value of the biological parameter obtained from a functionally visualizing study of the object. ! 2. The device according to claim 1, in which the device iteratively adjusts the desired therapy based on the observed reaction to the applied therapy. ! 3. The device according to claim 2, in which the device iteratively adjusts the required therapy until the measured value (bi, measured) of the biological parameter reaches the desired value (bi, target). ! 4. The device according to claim 1, in which the pathology model is an empirically derived model showing the response of a set of objects to the therapy of the type to be used. ! 5. The device according to claim 1, in which the pathology model simulates a change in the value of a biological parameter depending on time. ! 6. The device according to claim 1, in which the data archive of object-specific biological parameters includes many spatially varying values of biological parameters. ! 7. The device according to claim 1, including a driver (102) of functional images. ! 8. The device according to claim 1, including a therapy calculation device (120) that calculates the therapy to be used by the therapy device (106). ! 9. The device according to claim 8, including a device (106) for therapy, functionally electrically communicating with the device for calculating therapy. ! one
机译:1.一种治疗目的地设备(118),其使用病理模型(122)和对象特定生物学参数的数据(124)的档案来建立期望的治疗(D),以应用于对象(101),同时病理模型模拟对治疗的病理反应,并且生物参数数据的存档包括从对象的功能可视化研究中获得的生物参数的值。 ! 2.根据权利要求1所述的设备,其中,所述设备基于所观察到的对所施加的治疗的反应来迭代地调整期望的治疗。 ! 3.根据权利要求2所述的设备,其中,所述设备迭代地调整所需的治疗,直到所述生物学参数的测量值(bi,测量的)达到期望值(bi,目标)为止。 ! 4.根据权利要求1所述的设备,其中,所述病理模型是根据经验得出的模型,其示出了一组对象对要使用的类型的疗法的响应。 ! 5.根据权利要求1所述的设备,其中,所述病理学模型模拟取决于时间的生物学参数值的变化。 ! 6.根据权利要求1至5中任一项所述的装置,其特征在于,所述特定对象的生物学参数的数据档案包括生物学参数的许多空间变化的值。 ! 7.根据权利要求1所述的设备,包括功能图像的驱动器(102)。 ! 8.根据权利要求1所述的设备,包括治疗计算设备(120),其计算要由所述治疗设备(106)使用的治疗。 ! 9.根据权利要求8所述的设备,包括用于治疗的设备(106),其与用于计算治疗的设备在功能上电连通。 !一

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