METHOD FOR OPTIMIZING TREATMENT OF LEUKOSIS POSITIVE FOR PHILADELPHIC CHROMOSOME, AB1-TYROZINKINASE INHIBITORS

摘要

1. A method for treating Philadelphia chromosome-positive leukemia (Ph + leukemia) in a group of human patients, comprising the steps of:! (a) administering a predetermined fixed amount of imatinib or a pharmaceutically acceptable salt thereof to human patients with Ph + leukemia,! (b) taking at least one blood sample from these patients during the first three months of treatment,! (c) determining the minimum plasma level (Cmin) of imatinib,! (d) selecting a dose of imatinib or a pharmaceutically acceptable salt thereof in such a way that the Cmin value between about 1000 and about 3000 ng / ml imatinib achieved in each individual patient does not exceed the Cmin threshold value between about 1000 and about 3000 ng / ml imatinib. ! 2. A method for the treatment of chronic myeloid leukemia (CML) in a group of human patients, comprising the steps of:! (a) administering a predetermined fixed amount of imatinib or a pharmaceutically acceptable salt thereof to CML patients in need thereof! (b) taking at least one blood sample from these patients during the first three months of treatment,! (c) determining the minimum plasma level (Cmin) of imatinib,! and (d) selecting a dose of imatinib or a pharmaceutically acceptable salt thereof in such a way that the Cmin between about 1000 and about 3000 ng / ml imatinib achieved in each individual patient does not exceed the Cmin threshold between about 1000 and about 3000 ng / ml imatinib . ! 3. The method according to claim 2, in which the salt of imatinib monomesylate is administered. ! 4. The method according to claim 3, in which at the stage (a) the daily dose is approximately