首页> 外国专利> System, useful e.g. to produce a medicament to treat malignant diseases and metastatic tumors and for the isolation of a specific element of a molecular library, comprises a reaction chamber partitioned into a number of compartments

System, useful e.g. to produce a medicament to treat malignant diseases and metastatic tumors and for the isolation of a specific element of a molecular library, comprises a reaction chamber partitioned into a number of compartments

机译:系统,例如生产一种用于治疗恶性疾病和转移性肿瘤以及分离分子库特定元素的药物,包括一个反应室,该反应室被划分为多个隔室

摘要

System for the isolation of a specific element E of a molecular library E1, comprises a reaction chamber partitioned into a number of compartments K 1-n, where each compartments K xapart from the physical structure of the compartment-forming components comprise (A) an element E xfrom the molecular library E1 and (B) an element M xfrom a library of physically manifested structural information M1, which is provided that to each E xbelonged to E1 at least a M xbelonged to M1 is arranged, which alone or in combination with E1 an identification and/or characterization of M xis allowed. System for the isolation of a specific element E of a molecular library E1, comprises a reaction chamber partitioned into a number of compartments K 1-n, where each compartments K xapart from the physical structure of the compartment-forming components comprise (A) an element E xfrom the molecular library E1 and (B) an element M xfrom a library of physically manifested structural information M1, which is provided that to each E xbelonged to E1 at least a M xbelonged to M1 is arranged, which alone or in combination with E1 an identification and/or characterization of M xis allowed, so that a logical connection between the E xand M xis produced by the common physical presence of E xand M xwithin a compartment. Independent claims are included for: (1) a method for providing a nucleic acid sequence and a peptide sequence, comprising using the system; (2) the nucleic acid sequence, provided by the system; (3) a polypeptide sequence, which is encoded by a nucleic acid sequence; (4) an affinity mediating molecule comprising a nucleic acid sequence or a polypeptide sequence; (5) a drug delivery system comprising the affinity mediating molecule; (6) a transgenic non-human organism comprising a nucleic acid sequence, polypeptide sequence, affinity binding molecule, or a sequence with significant homology to any of the sequences; (7) a plant comprising a transgenic non-human organism; (8) a method for producing a transgenic non-human organism, comprising obtaining the transgene using the system; (9) a method for producing nitrogenous biomass, where an organism holds under conditions, in which nitrogen deficiency is the limiting factor; (10) a method for producing biomass, hydrocarbons, polyhydroxy compounds, sugars and polyalkoxy compounds from atmospheric carbon dioxide, where an organism holds under permissive growth conditions; (11) a method for ameliorating inferior soils, comprising contacting an organism under permissive growth conditions with the inferior soils; (12) a method for the treatment of waste water, comprising contacting an organism under permissive growth conditions with the waste water; (13) a method for producing nut protein, comprising expressing the nut protein in an organism; (14) a method for reducing hydrophobic contaminants in natural habitats, comprising contacting the organism with the habitat; (15) a method for combating mosquitoes, comprising contacting an organism with the habitat of the mosquito larvae; (16) a method for combating trematodes, comprising contacting an organism with the habitat of an invertebrate, aquatic intermediate hosts of trematodes; (17) a food for animals or humans, where the raw material is produced or comprises an organism; (18) a paper, cardboard, corrugated cardboard, pulp, carton or wool, where the underlying cellulose is obtained from an organism; (19) a fuel or propellant, fuel- or propellant-additive or lubricant, and a plastic material, where the carbon source comprises an organism; (20) a method for the irrigation of farmland, where an organism holds in an open irrigation system; (21) a method for determination of the activity of a chaperone; (22) a method for producing a transgenic plant cell, where the transgenic plant cell is a transgenic organism and comprises the method of the identification of a chaperone; (23) a method (A) for in vitro identification of the resistance of a transgenic cell against irreversible inactivation by at least one abiotic stress factor compared to the wild-type cell-enhancing nucleic acid- or polypeptide sequence; (24) a liposome, obtained by the method (A); (25) a pharmaceutical formulation comprising the liposome; (26) a transgenic plant cell, produced by the method or a progeny of cell produced by division, budding or fusion; (27) a method (B) for reducing the carbon dioxide concentration in a gas stream, comprising contacting the gas stream directly or indirectly to an organism; (28) a method for the neutralization of acid in an aqueous medium, comprising contacting the aqueous medium with an organism; (29) a method (C) for the degradation of waste containing hydrocarbons, comprising contacting an organism comprising a cell with the waste; (30) an apparatus for pollution control, comprising an organism or which implements a method (B); (31) a device for providing heat or electricity, comprising the apparatus; and (32) an appliance for disposal of waste, which implements a method (C). ACTIVITY : Antiinflammatory; Cytostatic; Immunosuppressive; Cardiovascular-Gen.; Neuroprotective; Nootropic. MECHANISM OF ACTION : None given.
机译:用于分离分子文库E1的特定元素E的系统,包括一个划分为多个小室K 1-n的反应室,其中每个小室K x除了形成小室的组分的物理结构外,还包括(A)来自分子库E1的元素E x和(B)来自物理表现的结构信息M1的库的元素M x,条件是,对于属于E 1的每个E x,至少布置了属于M 1的M x,其单独或组合E1允许对M x进行标识和/或表征。用于分离分子文库E1的特定元素E的系统,包括一个划分为多个小室K 1-n的反应室,其中每个小室K x除了形成小室的组分的物理结构外,还包括(A)来自分子库E1的元素E x和(B)来自物理表现的结构信息M1的库的元素M x,条件是,对于属于E 1的每个E x,至少布置了属于M 1的M x,其单独或组合E1允许对M x进行标识和/或表征,因此E x和M x之间的逻辑连接是通过隔室内E x和M x的共同物理存在而产生的。包括以下独立权利要求:(1)提供核酸序列和肽序列的方法,包括使用所述系统; (2)系统提供的核酸序列; (3)由核酸序列编码的多肽序列; (4)一种亲和介导分子,其包含核酸序列或多肽序列; (5)包含亲和介导分子的药物递送系统; (6)一种转基因非人生物,其包含核酸序列,多肽序列,亲和结合分子或与任何序列具有显着同源性的序列; (7)包含转基因非人类生物的植物; (8)一种生产转基因非人类生物的方法,包括使用该系统获得转基因。 (9)一种生产含氮生物质的方法,其中生物体处于氮不足为限制因素的条件下; (10)一种方法,其用于从大气二氧化碳中产生生物质,碳氢化合物,多羟基化合物,糖和聚烷氧基化合物,其中生物体处于允许的生长条件下; (11)一种改善下层土壤的方法,包括使有机体在允许的生长条件下与下层土壤接触; (12)一种废水处理方法,包括使生物在允许的生长条件下与废水接触; (13)一种坚果蛋白的生产方法,其包括在生物体中表达所述坚果蛋白。 (14)一种减少自然生境中疏水性污染物的方法,包括使生物体与生境接触; (15)一种灭蚊方法,其包括使生物与蚊幼虫的栖息地接触。 (16)一种防治吸虫的方法,包括使生物体与无脊椎动物,水生吸虫中间宿主的生境接触。 (17)生产动物原料或包含生物的动物或人类食品; (18)纸,纸板,瓦楞纸板,纸浆,纸箱或羊毛,其中底层纤维素是从生物体获得的; (19)燃料或推进剂,燃料或推进剂添加剂或润滑剂以及塑料,其中碳源包括生物; (20)一种农田灌溉方法,其中一种生物体处于开放式灌溉系统中; (21)一种测定伴侣活性的方法。 (22)一种转基因植物细胞的制造方法,其中,所述转基因植物细胞是转基因生物,并且包括分子伴侣的鉴定方法。 (23)一种方法(A),与野生型细胞增强核酸或多肽序列相比,体外鉴定转基因细胞对至少一种非生物胁迫因子的不可逆失活的抗性; (24)通过方法(A)得到的脂质体。 (25)包含脂质体的药物制剂。 (26)通过该方法产生的转基因植物细胞或通过分裂,出芽或融合产生的细胞后代; (27)一种降低气流中二氧化碳浓度的方法(B),包括使气流直接或间接接触生物体; (28)中和水性介质中的酸的方法,其包括使水性介质与生物接触。 (29)一种降解含烃废物的方法(C),包括使包含细胞的生物与废物接触; (30)一种污染控制装置,其包括生物或实施方法(B); (31)供热或通电的装置,包括该设备; (32)实施方法(C)的废物处理设备。活性:抗炎;细胞抑制免疫抑制心血管创具有神经保护作用;促智。作用机理:未给出。

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