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efficient inhibition of the entry of hiv-1 virus by a new fusion protein with cd4
efficient inhibition of the entry of hiv-1 virus by a new fusion protein with cd4
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机译:与cd4的新融合蛋白有效抑制hiv-1病毒的进入
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摘要
Nucleic acids encoding recombinant CD4-fusion proteins are disclosed herein that include a CD4 polypeptide ligated at its C-terminus with a portion of an immunoglobulin comprising a hinge region and a constant domain of a mammalian immunoglobulin heavy chain. The portion of the IgG is fused at its C-terminus with a polypeptide comprising a tailpiece from the C terminus of the heavy chain of an IgA antibody or a tailpiece from a C terminus of the heavy chain of an IgM antibody. Also disclosed herein are methods for using these CD4-fusion proteins.
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