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Improved differentiation and determination of ionic conformations by combining ion mobility and hydrogen deuterium exchange reactions
Improved differentiation and determination of ionic conformations by combining ion mobility and hydrogen deuterium exchange reactions
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机译:通过结合离子迁移率和氢氘交换反应,改善了离子构象的区分和确定
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摘要
A mass spectrometer is disclosed comprising a hydrogen-deuterium exchange cell. Isomeric ions having different conformations but substantially similar ion mobilities can be differentiated by subjecting the ions to hydrogen-deuterium exchange. Two ions having similar ion mobilities can be differentiated more effectively if they have different surface conformations by determining the relative degree of hydrogen-deuterium exchange.
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