DENDRITIC CELL COSTIMULATORY MOLECULE

摘要

PROBLEM TO BE SOLVED: To provide genes encoding novel dendritic cell (DC) specific costimulatory molecules for T cell activation.SOLUTION: A costimulatory protein molecule, B7-DC, is a member of the B7 family, and DNA coding therefor and expression vectors comprising this DNA are described. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell-mediated responses can be harnessed for anti-tumor and anti-viral immunity.