FUSED-ARYL AND HETEROARYL DERIVATIVE AS MODULATOR OF METABOLISM AND PROPHYLAXIS AND TREATMENT OF DISORDER RELATED TO METABOLISM

摘要

PPROBLEM TO BE SOLVED: To provide modulators of metabolism. PSOLUTION: There are provided certain fused-aryl and heteroaryl derivatives of formula (I) that are modulators of metabolism. Accordingly, the compounds are useful in the prophylaxis or treatment of metabolic disorders and complications thereof (such as, diabetes and obesity). A compound bonding to GPCR called RUP3 in the specification and modulating the activity of GPCR, and uses thereof, are provided. The term RUP3 includes human sequences shown in Genbank Accession Number XM_066873 and AY288416, naturally existing allele variants of the sequence, mammalian orthologs thereof, and recombinant variants thereof. PCOPYRIGHT: (C)2011,JPO&INPIT