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MAL, a molecular diagnostic marker for HPV-induced invasive cancer and its highly malignant precursor lesions
MAL, a molecular diagnostic marker for HPV-induced invasive cancer and its highly malignant precursor lesions
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机译:MAL,HPV诱导的浸润性癌及其高度恶性前体病变的分子诊断标志物
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摘要
The inventors now have developed a (molecular) diagnostic marker based on MAL alterations, in particular reduced MAL mRNA and protein expression as well as MAL promoter hypermethylation, to identify human papillomavirus (HPV)-induced high-grade precancerous lesions such as premalignant cervical lesions of invasive cervical cancer, and high-risk human papillomavirus (HPV)-induced precursor lesions of non-cervical invasive cancers within, cell material obtained via scraping, lavage or by other means and/or tissue. In particular, the present invention relates to the use of the MAL gene (including its promoter) and the gene products thereof as marker for HPV-induced high-grade premalignant lesions, allowing early detection and better treatment option for the individual patient.
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