Preventive and therapeutic agent for disorders caused by toxicity of quinone body or quinone precursor

摘要

PROBLEM TO BE SOLVED: To provide a medical agent effective to toxicity originated from a quinone compound or a precursor of quinone compound produced by oxidation of an exotic medical agent, or endogenous amines, amino acids or proteins, and specifically effective to cranial neuropathy and/or cytopathy.;SOLUTION: The invention relates to the suppressant of toxicity due to the quinone compound or precursor of the quinone compound comprising a compound selected from a group comprising dopamine receptor agonist (dopamine agonist). Dopamine receptor agonist such as bromocriptine mesilate, pergolide mesilate, talipexole hydrochloride, ropinirole hydrochloride, pramipexole hydrochloride, etc., has activities directly bonding to dopamine quinone compound or dopa quinone compound itself, and capturing and erasing. The suppressant exerts an excellent suppressing effect in a group administered with levodopa on cranial neuropathy caused by production of intracerebral quinone compounds.;COPYRIGHT: (C)2006,JPO&NCIPI