PREVENTIVE AND THERAPEUTIC AGENT AND DISORDER OF TUNICA MUCOSA VENTRICULI CAUSED BY SHOCK

摘要

PURPOSE: To obtain the subject therapeutic agent useful for hemorrhagic shock, having protecting action on disorder of tunica mucosa ventriculi caused by shock in mammals, preventing ischemia of tunica mucosa ventriculi by improvement in microcirculation, comprising a prescribed antithrombin derived from human as an active ingredient. ;CONSTITUTION: This therapeutic agent contains human-derived antithrombin-III as an active ingredient. For example, fraction IV-1, fraction IV, supernatant liquid I or supernatant liquid II+III by Cohn fractionation method of plasm is used as a starting substance for preparation. Or the substance may be prepared by a cell culture method. A dose is preferably 10-500 units/kg weight/day (1 unit is an amount of the antithrombin-III contained in 1ml human plasma).;COPYRIGHT: (C)1996,JPO