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Regulatory sequences and expression systems that function in filamentous fungi
Regulatory sequences and expression systems that function in filamentous fungi
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机译:在丝状真菌中起作用的调控序列和表达系统
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摘要
The present invention provides a promoter and a terminator which coordinately function with the expression of an endogenous gene in a filamentous fungus that belongs to Agonomycetes, particularly in Mycelia sterilia. A promoter of the present invention comprises the nucleotide sequence of SEQ ID NO: 1 and a homologue thereof. A terminator of the present invention comprises the nucleotide sequence of SEQ ID NO: 2 and a homologue thereof. The present invention further provides an expression vector that highly expresses a protein of interest in a filamentous fungus, a transformed filamentous fungus that highly produces a protein of interest, and a process of producing the protein of interest in the transformed filamentous fungus. IMAGE
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机译:本发明提供了一种启动子和终止子,它们与属于农杆菌的丝状真菌,特别是在菌丝体中的内源基因的表达具有协调功能。本发明的启动子包含SEQ ID NO:1的核苷酸序列及其同源物。本发明的终止子包含SEQ ID NO:2的核苷酸序列及其同源物。本发明进一步提供了一种表达载体,其在丝状真菌中高表达目的蛋白,高度产生目的蛋白的转化的丝状真菌,以及在转化的丝状真菌中产生目的蛋白的方法。 <图像>
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