Three-dimensional arrays and methods of using the same support carrier for the solid-phase parallel synthesis

摘要

To adapt to provide a (3D) Diversity three-dimensional parallel synthesis of molecular libraries, a 3D array (57) of the solid phase [Abstract] support carrier. It can be synthesized in a position assigned to selected molecules in the library the position of individual 3D array, assigned molecules, and to be recovered from. Also includes a wall of the opening of the plate stack to the support carrier; be suspended in the opening of the plate support supporting a stack is to be; 3D array wherein is arranged in the form of a column in the wells of one or more can support supporting said suspending the tube, or including the inner walls of the tube, the tube is fixed to (2D) framework dimensional stacked; includes a support separate carrier was or, the support carrier and a bead that is contained within a porous enclosure which is fixed to the 2D framework that is stacked and having a side wall of the non-porous. Support carrier mobile device allows movement of the solid phase support carrier used in the 3D array. Such a device, mechanism to prevent the support carrier (rack, shelving) and being disengaged from the rack the rack consisting rod is sized to extend through the support carrier; support carrier Z on one plane at a time a plurality of tubes connected to the vacuum manifold sucking up; when in the closed position and the recess accommodates the support carrier or one or more, the moving block having at least one gate that prevents support carrier from passing through the gate, I include the. The method of 3D synthesis, to introduce a functional group a) the carrier solid phase support; including implementing a parallel synthesis with c) 3D and diversity, that; to be placed in the form of a 3D array b) support carrier. Can be assigned to each plane Z R ₁ group unique member of at least one.