COMPOSITIONS AND METHODS FOR PRODUCING REPLICATION COMPETENT HUMAN IMMUNODEFICIENCY VIRUS (HIV)

摘要

The invention provides methods for producing a replication competent chimeric human immunodeficiency virus (HIV) that optionally contains a heterologous reporter gene, and methods for generating these viruses. The invention's recombinant viruses are useful in the determination of, for example, antiretroviral drug susceptibility, HIV drug resistance, HIV phenotyping, HIV genotyping, HIV fitness, HIV tropism or coreceptor usage, HIV serum neutralization, and for HIV vaccine development, HIV vector development, and HIV virus production.