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Systems and methods of promoting endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft in a mammal
Systems and methods of promoting endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft in a mammal
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机译:在哺乳动物中促进混合血液透析通路移植物或混合股动脉旁路移植物内皮化的系统和方法
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摘要
Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid graft.
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