METHOD FOR PRODUCING LANGERHANS CELLS OR INTERSTITIAL DENDRITIC CELLS OR BOTH FROM CD14+ MONOCYTES

摘要

The present invention relates to a method for preparing Langerhans cells or interstitial dendritic cells or both from CD14⁺ monocytes stemming from the peripheral circulatory blood of a living being, wherein the method comprises differentiation of CD 14⁺ monocytes into either Langerhans cells, interstitial dendritic cells, or into both types of cells by placing the CD14⁺ monocytes in the presence of a cell environment comprising epithelial cells and/or mesenchymatous cells.;The present invention also relates to cell or tissue models comprising such prepared Langerhans cells and/or interstitial dendritic cells, and optionally macrophages and endothelial cells, and to the uses of such cell or tissue models.