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USE OF NON-CATALYTIC FORM OF HEPARANASE AND PEPTIDES THEREOF FOR REVERSING THE ANTI-COAGULANT EFFECTS OF HEPARINOIDS
USE OF NON-CATALYTIC FORM OF HEPARANASE AND PEPTIDES THEREOF FOR REVERSING THE ANTI-COAGULANT EFFECTS OF HEPARINOIDS
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机译:肝素酶及其肽的非催化形式用于逆转类肝素的抗凝作用
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摘要
The present invention relates to inhibition of heparinoids anti-coagulation activity by a non-active form of a eukaryotic endoglycosidase or any fragment or peptide thereof comprising at least one heparin-binding domain. More particularly, the invention provides compositions and methods for the inhibition of heparinoids anti-coagulation activity and for the treatment of coagulation related pathologic clinical conditions, using a non-active form of mammalian heparanase or peptides thereof comprising at least one heparin-binding domain.
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