Methods for Modulating a PDGF-AA Mediated Biological Response

摘要

The present invention is directed towards methods and means for modulating PDGF-AA mediated biological responses and is based, at least in part, on examining the association of various proteins with TMEFF2 and identification of PDGF-AA as a major growth factor that interacts specifically with TMEFF2. The invention provides the first evidence that TMEFF2 can function to regulate PDGF signaling, to help illuminate the seemingly conflicting biological roles of TMEFF2 in human cancers.