Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon

摘要

Provided herein are antibodies, fragments and derivatives of an antibody containing a binding domain thereof, where the antibody, fragment or derivative specifically binds to a single chain protease domain of a type II transmembrane serine protease (MTSP). Methods using the antibodies to modulate the protease activity of an MTSP are provided. Also provided are antibodies that bind to MTSPs designated MTSP3 and MTSP4 and to a form of an MTSP designated MTSP6.