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Method for producing human antibodies to a self physiological receptor by site-directed in vitro immunization of human lymphocytes
Method for producing human antibodies to a self physiological receptor by site-directed in vitro immunization of human lymphocytes
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机译:通过对人淋巴细胞进行定点体外免疫来产生针对自身生理受体的人抗体的方法
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摘要
A method for obtaining agonist, antagonist and inverse agonist, to a given physiological receptor is disclosed. For the method, use is made of in silico design synthetic immunogens, which are caused to act in vitro on human lymphocyte-containing cell populations. A preferred receptor is human CD152, particularly the regions of CDR1, CDR2 and CDR3 that elicit antibodies serving as antagonist, inverse agonist and agonist, respectively. Also provided is a method in the treatment of human peripheral lymphocytes for use in the screening of CD152 ligands that yield pharmacological effects.
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